| 1. Jornada | 24.07.2021 | FK Dinamo Makhachkala | - | FK Druzhba | 3:0 | ||||
| 3. Jornada | 07.08.2021 | FK Tuapse | - | FK Druzhba | 3:0 | ||||
| 6. Jornada | 29.08.2021 | FK Druzhba | - | Chernomorets Novorossisk | 0:1 | ||||
| 7. Jornada | 04.09.2021 | FK Yessentuki | - | FK Druzhba | 2:1 | ||||
| 17. Jornada | 06.11.2021 | FK Druzhba | - | Forte Taganrog | 1:2 | ||||
| 21. Jornada | 06.04.2022 | FK Druzhba | - | Dinamo Stavropol | 4:1 | ||||
| 25. Jornada | 10.04.2022 | FK Druzhba | - | FK Legion Dynamo Makhachkala | 1:1 |  |
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| 28. Jornada | 30.04.2022 | FK Chayka | - | FK Druzhba | 3:0 | ||||
| 29. Jornada | 06.05.2022 | FK Druzhba | - | Anzhi Makhachkala | 2:2 | ||||
| 31. Jornada | 16.05.2022 | Alania-2 Vladikavkaz | - | FK Druzhba | 1:2 | ||||
| 33. Jornada | 29.05.2022 | Forte Taganrog | - | FK Druzhba | 1:0 | ||||
| 34. Jornada | 05.06.2022 | FK Druzhba | - | FK Dinamo Makhachkala | 1:2 | |
Rusia