| 14. Jornada | 21.11.2021 | Servette FC | - | Grasshopper Club Zürich | 3:2 | ||||
| 15. Jornada | 27.11.2021 | Grasshopper Club Zürich | - | FC Lugano | 0:1 | ||||
| 16. Jornada | 05.12.2021 | FC St. Gallen | - | Grasshopper Club Zürich | 0:4 | ||||
| 19. Jornada | 30.01.2022 | FC Sion | - | Grasshopper Club Zürich | 2:0 |  |
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| 29. Jornada | 09.04.2022 | Grasshopper Club Zürich | - | FC Luzern | 2:2 | ||||
| 30. Jornada | 16.04.2022 | Servette FC | - | Grasshopper Club Zürich | 0:1 | ||||
| 31. Jornada | 24.04.2022 | Grasshopper Club Zürich | - | FC Lausanne-Sport | 3:1 | ||||
| 36. Jornada | 22.05.2022 | BSC Young Boys | - | Grasshopper Club Zürich | 3:0 |
Portugal