| 1. Jornada | 19.02.2022 | Emelec | - | Macará | 4:0 |  |
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| 2. Jornada | 01.03.2022 | Macará | - | Orense SC | 1:0 | ||||
| 3. Jornada | 06.03.2022 | Delfín SC | - | Macará | 1:0 | |
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| 4. Jornada | 13.03.2022 | Universidad Catolica | - | Macará | 2:2 | |
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| 5. Jornada | 20.03.2022 | Macará | - | Guayaquil City | 2:0 | ||||
| 6. Jornada | 05.04.2022 | Macará | - | Cumbayá | 0:0 | |
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| 7. Jornada | 12.04.2022 | Aucas | - | Macará | 2:0 | ||||
| 8. Jornada | 17.04.2022 | Macará | - | Deportivo Cuenca | 0:1 | ||||
| 11. Jornada | 30.04.2022 | Gualaceo SC | - | Macará | 2:1 | ||||
| 15. Jornada | 30.05.2022 | LDU Quito | - | Macará | 3:2 |
Paraguay