| 8. Jornada | 22.02.2021 | Santa Fe | - | Independiente Medellín | 0:0 | ||||
| 9. Jornada | 25.02.2021 | Santa Fe | - | Boyacá Chicó | 2:0 | ||||
| 10. Jornada | 01.03.2021 | Deportivo Cali | - | Santa Fe | 1:1 | ||||
| 11. Jornada | 09.03.2021 | Santa Fe | - | Deportivo Pasto | 2:2 | ||||
| 13. Jornada | 20.03.2021 | Envigado FC | - | Santa Fe | 2:1 | ||||
| 17. Jornada | 07.04.2021 | Alianza Petrolera | - | Santa Fe | 0:3 |  |
|||
| 18. Jornada | 12.04.2021 | Santa Fe | - | Millonarios | 1:2 |  |
Colombia
México 