| 1. Jornada | 20.07.2014 | CD Veracruz | - | Santos Laguna | 0:1 |  |
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| 2. Jornada | 26.07.2014 | Santos Laguna | - | Cruz Azul | 1:1 | |
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| 3. Jornada | 03.08.2014 | CF Monterrey | - | Santos Laguna | 0:0 | ||||
| 4. Jornada | 10.08.2014 | Santos Laguna | - | Gallos Blancos | 2:3 | ||||
| 5. Jornada | 18.08.2014 | Deportivo Guadalajara | - | Santos Laguna | 0:1 | ||||
| 6. Jornada | 23.08.2014 | Santos Laguna | - | Deportivo Toluca | 3:0 | |
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| 7. Jornada | 31.08.2014 | Atlas Guadalajara | - | Santos Laguna | 1:1 | ||||
| 8. Jornada | 13.09.2014 | Santos Laguna | - | Club León | 2:0 | |
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| 9. Jornada | 20.09.2014 | Club Tijuana | - | Santos Laguna | 4:1 | ||||
| 10. Jornada | 27.09.2014 | Santos Laguna | - | CF América | 1:4 | ||||
| 11. Jornada | 01.10.2014 | UANL Tigres | - | Santos Laguna | 1:1 | ||||
| 12. Jornada | 05.10.2014 | Santos Laguna | - | Monarcas Morelia | 2:2 | |
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| 13. Jornada | 19.10.2014 | Chiapas FC | - | Santos Laguna | 2:0 |  |
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| 15. Jornada | 02.11.2014 | Leones Negros | - | Santos Laguna | 1:1 | ||||
| 16. Jornada | 08.11.2014 | Santos Laguna | - | CF Pachuca | 2:1 | |
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| 17. Jornada | 23.11.2014 | Puebla FC | - | Santos Laguna | 3:3 | |
Colombia
México 