| 1. Jornada | 24.07.2021 | FK SKA Rostov | - | Spartak Nalchik | 0:0 | ||||
| 2. Jornada | 01.08.2021 | FK Chayka | - | FK SKA Rostov | 0:1 | ||||
| 3. Jornada | 08.08.2021 | FK SKA Rostov | - | Anzhi Makhachkala | 0:1 |  |
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| 4. Jornada | 15.08.2021 | FK Druzhba | - | FK SKA Rostov | 1:4 | ||||
| 5. Jornada | 21.08.2021 | FK SKA Rostov | - | Alania-2 Vladikavkaz | 5:0 | ||||
| 6. Jornada | 29.08.2021 | Kuban-Holding Pavlovskaya | - | FK SKA Rostov | 1:2 | ||||
| 7. Jornada | 04.09.2021 | FK SKA Rostov | - | Forte Taganrog | 5:2 | ||||
| 8. Jornada | 08.09.2021 | FK Dinamo Makhachkala | - | FK SKA Rostov | 0:1 | ||||
| 9. Jornada | 12.09.2021 | FK SKA Rostov | - | Rotor-2 Volgograd | 1:0 |  |
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| 10. Jornada | 20.09.2021 | FK Tuapse | - | FK SKA Rostov | 0:3 | ||||
| 12. Jornada | 03.10.2021 | FK SKA Rostov | - | Dinamo Stavropol | 2:1 | |
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| 13. Jornada | 10.10.2021 | Chernomorets Novorossisk | - | FK SKA Rostov | 0:1 | |
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| 15. Jornada | 23.10.2021 | FK Biolog Novokubansk | - | FK SKA Rostov | 1:3 | |
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| 16. Jornada | 31.10.2021 | FK SKA Rostov | - | FK Legion Dynamo Makhachkala | 2:1 | |
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| 18. Jornada | 14.11.2021 | FK SKA Rostov | - | FK Chayka | 0:2 | |
Rusia