| 1. Jornada | 24.07.2021 | NK Veres | - | Kolos Kovalivka | 0:0 | ||||
| 2. Jornada | 30.07.2021 | Kolos Kovalivka | - | Metalist 1925 Kharkiv | 1:0 | ||||
| 5. Jornada | 22.08.2021 | Kolos Kovalivka | - | FK Oleksandriya | 0:1 |  |
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| 6. Jornada | 28.08.2021 | Dinamo Kiev | - | Kolos Kovalivka | 7:0 | ||||
| 7. Jornada | 12.09.2021 | Kolos Kovalivka | - | FK Mariupol | 1:3 | ||||
| 8. Jornada | 18.09.2021 | Inhulets Petrove | - | Kolos Kovalivka | 0:2 | |
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| 9. Jornada | 24.09.2021 | Kolos Kovalivka | - | Vorskla Poltava | 0:1 | ||||
| 11. Jornada | 16.10.2021 | SK Dnipro-1 | - | Kolos Kovalivka | 2:0 | |
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| 12. Jornada | 24.10.2021 | Zorya Lugansk | - | Kolos Kovalivka | 1:0 | ||||
| 14. Jornada | 07.11.2021 | Kolos Kovalivka | - | Shakhtar Donetsk | 1:3 | ||||
| 15. Jornada | 21.11.2021 | Desna Chernigov | - | Kolos Kovalivka | 0:1 | |
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| 16. Jornada | 28.11.2021 | Kolos Kovalivka | - | NK Veres | 1:0 | ||||
| 17. Jornada | 04.12.2021 | Metalist 1925 Kharkiv | - | Kolos Kovalivka | 0:1 | ||||
| 18. Jornada | 12.12.2021 | Kolos Kovalivka | - | FC Mynai | 2:1 |
Ucrania