| 22. Jornada | 14.01.2022 | Telstar | - | MVV | 2:1 | ||||
| 23. Jornada | 21.01.2022 | MVV | - | FC Volendam | 0:1 | ||||
| 24. Jornada | 29.01.2022 | FC Eindhoven | - | MVV | 1:0 | ||||
| 25. Jornada | 04.02.2022 | MVV | - | VVV-Venlo | 0:5 | ||||
| 28. Jornada | 25.02.2022 | FC Dordrecht | - | MVV | 3:1 | ||||
| 29. Jornada | 04.03.2022 | MVV | - | NAC Breda | 1:2 |  |
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| 30. Jornada | 11.03.2022 | FC Den Bosch | - | MVV | 3:1 | ||||
| 27. Jornada | 14.03.2022 | MVV | - | AZ Alkmaar (J) | 2:3 | ||||
| 32. Jornada | 27.03.2022 | MVV | - | Almere City FC | 0:3 | ||||
| 33. Jornada | 01.04.2022 | Helmond Sport | - | MVV | 1:2 | ||||
| 34. Jornada | 08.04.2022 | MVV | - | FC Utrecht (J) | 2:4 | ||||
| 35. Jornada | 15.04.2022 | MVV | - | SBV Excelsior | 1:1 | ||||
| 36. Jornada | 25.04.2022 | Jong PSV | - | MVV | 2:2 | |
Países Bajos