| 2. Jornada | 16.01.2022 | Club Tijuana [Sub 20] | - | Club León [Sub 20] | 1:2 | ||||
| 1. Jornada | 19.01.2022 | Club León [Sub 20] | - | Atlas Guadalajara [Sub 20] | 1:1 |  |
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| 3. Jornada | 22.01.2022 | Club León [Sub 20] | - | CF Pachuca [Sub 20] | 4:3 | ||||
| 4. Jornada | 07.02.2022 | Club León [Sub 20] | - | Cruz Azul [Sub 20] | 2:1 | ||||
| 7. Jornada | 25.02.2022 | Club Necaxa [Sub 20] | - | Club León [Sub 20] | 0:3 | ||||
| 8. Jornada | 01.03.2022 | Club León [Sub 20] | - | CF Monterrey [Sub 20] | 1:2 | ||||
| 10. Jornada | 12.03.2022 | Club León [Sub 20] | - | UANL Tigres [Sub 20] | 2:1 | ||||
| 14. Jornada | 16.04.2022 | Club León [Sub 20] | - | Puebla FC [Sub 20] | 4:1 | |
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| 15. Jornada | 20.04.2022 | CF América [Sub 20] | - | Club León [Sub 20] | 2:1 | ||||
| 16. Jornada | 24.04.2022 | Santos Laguna [Sub 20] | - | Club León [Sub 20] | 0:3 | |
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| 17. Jornada | 01.05.2022 | Club León [Sub 20] | - | Deportivo Toluca [Sub 20] | 3:1 |
México