| 1. Jornada | 18.07.2010 | Club Olimpia | - | Sport Colombia | 3:0 |  |
|||
| 4. Jornada | 07.08.2010 | 3 de Febrero | - | Sport Colombia | 0:3 | ||||
| 5. Jornada | 14.08.2010 | Sport Colombia | - | Guaraní | 1:1 |  |
|||
| 7. Jornada | 29.08.2010 | Sport Colombia | - | Club Nacional | 1:2 | |
|||
| 16. Jornada | 24.10.2010 | Guaraní | - | Sport Colombia | 3:0 | |
|||
| 17. Jornada | 30.10.2010 | Tacuary | - | Sport Colombia | 2:1 | ||||
| 18. Jornada | 06.11.2010 | Club Nacional | - | Sport Colombia | 4:3 | ||||
| 21. Jornada | 28.11.2010 | Sport Colombia | - | Sportivo Luqueño | 0:0 | ||||
| 22. Jornada | 05.12.2010 | Sport Colombia | - | Cerro Porteño | 1:1 |
Paraguay