| 1. Jornada | 25.07.2021 | Metalist 1925 Kharkiv | - | Rukh Lviv | 2:1 |  |
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| 2. Jornada | 30.07.2021 | Kolos Kovalivka | - | Metalist 1925 Kharkiv | 1:0 | ||||
| 3. Jornada | 06.08.2021 | Metalist 1925 Kharkiv | - | Chernomorets Odessa | 3:2 | ||||
| 4. Jornada | 13.08.2021 | Shakhtar Donetsk | - | Metalist 1925 Kharkiv | 2:0 | |
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| 5. Jornada | 20.08.2021 | Vorskla Poltava | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 6. Jornada | 28.08.2021 | Metalist 1925 Kharkiv | - | SK Dnipro-1 | 1:2 | ||||
| 9. Jornada | 26.09.2021 | Desna Chernigov | - | Metalist 1925 Kharkiv | 1:2 | ||||
| 10. Jornada | 03.10.2021 | Metalist 1925 Kharkiv | - | FC Mynai | 1:0 | ||||
| 11. Jornada | 16.10.2021 | FK Mariupol | - | Metalist 1925 Kharkiv | 1:2 | |
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| 12. Jornada | 22.10.2021 | Metalist 1925 Kharkiv | - | Inhulets Petrove | 4:0 |  |
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| 14. Jornada | 05.11.2021 | FK Oleksandriya | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 15. Jornada | 22.11.2021 | NK Veres | - | Metalist 1925 Kharkiv | 2:0 | |
Ucrania