| 1. Jornada | 16.08.2021 | Gżira United | - | Hibernians FC | 1:3 | ||||
| 2. Jornada | 22.08.2021 | Hibernians FC | - | Gudja United | 2:1 | ||||
| 3. Jornada | 12.09.2021 | Sirens FC | - | Hibernians FC | 1:3 | ||||
| 4. Jornada | 18.09.2021 | Hibernians FC | - | Mosta FC | 3:2 | ||||
| 5. Jornada | 25.09.2021 | Hibernians FC | - | St. Luċija FC | 1:1 |  |
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| 6. Jornada | 17.10.2021 | Sliema Wanderers | - | Hibernians FC | 0:3 | ||||
| 7. Jornada | 24.10.2021 | Hibernians FC | - | Valletta FC | 1:1 | ||||
| 8. Jornada | 30.10.2021 | Birkirkara FC | - | Hibernians FC | 1:1 | ||||
| 9. Jornada | 21.11.2021 | Hibernians FC | - | Hamrun Spartans | 1:0 | ||||
| 10. Jornada | 28.11.2021 | Balzan FC | - | Hibernians FC | 1:2 | ||||
| 12. Jornada | 12.12.2021 | Hibernians FC | - | Gżira United | 3:1 | ||||
| 13. Jornada | 19.12.2021 | Gudja United | - | Hibernians FC | 1:2 | ||||
| 14. Jornada | 18.01.2022 | Hibernians FC | - | Sirens FC | 1:1 | ||||
| 15. Jornada | 22.01.2022 | Mosta FC | - | Hibernians FC | 1:1 |  |
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| 16. Jornada | 29.01.2022 | St. Luċija FC | - | Hibernians FC | 0:0 | ||||
| 18. Jornada | 12.02.2022 | Valletta FC | - | Hibernians FC | 1:4 | ||||
| 22. Jornada | 12.03.2022 | Floriana FC | - | Hibernians FC | 1:4 |
Malta