| 1. Jornada | 23.02.2025 | Columbus Crew | - | Chicago Fire | 4:2 | ||||
| 2. Jornada | 02.03.2025 | New England Revolution | - | Columbus Crew | 0:1 | ||||
| 3. Jornada | 08.03.2025 | Columbus Crew | - | Houston Dynamo | 0:0 | ||||
| 4. Jornada | 16.03.2025 | San Diego FC | - | Columbus Crew | 1:1 | ||||
| 5. Jornada | 23.03.2025 | Columbus Crew | - | New York City FC | 0:0 | ||||
| 6. Jornada | 30.03.2025 | D.C. United | - | Columbus Crew | 1:2 | ||||
| 7. Jornada | 06.04.2025 | Columbus Crew | - | CF Montréal | 2:1 |  |
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| 8. Jornada | 14.04.2025 | St. Louis City SC | - | Columbus Crew | 1:2 | ||||
| 9. Jornada | 19.04.2025 | Columbus Crew | - | Inter Miami CF | 0:1 | ||||
| 10. Jornada | 27.04.2025 | Columbus Crew | - | San Jose Earthquakes | 2:1 | ||||
| 11. Jornada | 04.05.2025 | Columbus Crew | - | Charlotte FC | 4:2 | |
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| 12. Jornada | 11.05.2025 | Philadelphia Union | - | Columbus Crew | 2:2 | ||||
| 13. Jornada | 15.05.2025 | CF Montréal | - | Columbus Crew | 1:1 | ||||
| 15. Jornada | 25.05.2025 | Charlotte FC | - | Columbus Crew | 3:2 | ||||
| 16. Jornada | 29.05.2025 | Columbus Crew | - | Nashville SC | 2:2 | ||||
| 18. Jornada | 15.06.2025 | Columbus Crew | - | Vancouver Whitecaps | 2:1 | ||||
| 19. Jornada | 26.06.2025 | Columbus Crew | - | Atlanta United FC | 3:1 |
Estados Unidos