| 4. Jornada | 19.09.2020 | Pau FC | - | Guingamp | 0:1 | ||||
| 5. Jornada | 26.09.2020 | Guingamp | - | Grenoble Foot 38 | 1:0 | ||||
| 7. Jornada | 19.10.2020 | Guingamp | - | AJ Auxerre | 2:0 | ||||
| 8. Jornada | 24.10.2020 | Caen | - | Guingamp | 1:0 |  |
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| 9. Jornada | 31.10.2020 | Guingamp | - | FC Sochaux | 0:0 | ||||
| 10. Jornada | 07.11.2020 | Clermont Foot 63 | - | Guingamp | 0:0 | |
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| 11. Jornada | 23.11.2020 | Guingamp | - | AC Ajaccio | 2:2 | ||||
| 12. Jornada | 28.11.2020 | Rodez AF | - | Guingamp | 1:1 | ||||
| 13. Jornada | 01.12.2020 | Guingamp | - | Troyes | 1:2 | ||||
| 14. Jornada | 05.12.2020 | Toulouse | - | Guingamp | 2:2 | ||||
| 16. Jornada | 18.12.2020 | FC Chambly | - | Guingamp | 3:0 | ||||
| 17. Jornada | 22.12.2020 | Paris FC | - | Guingamp | 3:2 | ||||
| 18. Jornada | 05.01.2021 | Guingamp | - | Amiens SC | 2:2 | ||||
| 19. Jornada | 08.01.2021 | LB Châteauroux | - | Guingamp | 2:3 | |
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| 20. Jornada | 16.01.2021 | Guingamp | - | AS Nancy Lorraine | 0:0 | ||||
| 21. Jornada | 23.01.2021 | Havre AC | - | Guingamp | 1:1 | ||||
| 22. Jornada | 30.01.2021 | Guingamp | - | Pau FC | 2:3 |  |
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| 24. Jornada | 05.02.2021 | Guingamp | - | USL Dunkerque | 0:0 | ||||
| 25. Jornada | 13.02.2021 | AJ Auxerre | - | Guingamp | 1:1 |
Francia