| 2. Jornada | 02.07.2022 | Club Tijuana [] | - | Santos Laguna [] | 2:0 | ||||
| 5. Jornada | 23.07.2022 | Santos Laguna [] | - | Mazatlán FC [] | 5:0 | ||||
| 12. Jornada | 10.09.2022 | UANL Tigres [] | - | Santos Laguna [] | 0:2 | ||||
| 9. Jornada | 21.09.2022 | Club León [] | - | Santos Laguna [] | 4:1 | ||||
| 17. Jornada | 15.10.2022 | CF Monterrey [] | - | Santos Laguna [] | 1:1 | ||||
| 18. Jornada | 22.10.2022 | Santos Laguna [] | - | Club Tijuana [] | 1:0 |
México