| 1. Jornada | 23.02.2025 | Columbus Crew | - | Chicago Fire | 4:2 |  |
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| 3. Jornada | 09.03.2025 | FC Dallas | - | Chicago Fire | 1:3 | |
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| 4. Jornada | 15.03.2025 | Toronto FC | - | Chicago Fire | 1:2 | ||||
| 8. Jornada | 13.04.2025 | Chicago Fire | - | Inter Miami CF | 0:0 | |
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| 9. Jornada | 20.04.2025 | Chicago Fire | - | FC Cincinnati | 2:3 | |
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| 10. Jornada | 27.04.2025 | Nashville SC | - | Chicago Fire | 7:2 | ||||
| 11. Jornada | 04.05.2025 | Chicago Fire | - | Orlando City | 0:0 | |
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| 12. Jornada | 10.05.2025 | Chicago Fire | - | Atlanta United FC | 2:1 | ||||
| 14. Jornada | 18.05.2025 | Charlotte FC | - | Chicago Fire | 1:4 | |
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| 15. Jornada | 25.05.2025 | New York City FC | - | Chicago Fire | 3:1 |  |
Estados Unidos
México