| 1. Jornada | 13.09.2021 | Progreso | - | Villa Española | 1:1 |  |
|||
| 2. Jornada | 19.09.2021 | Nacional | - | Progreso | 0:1 | ||||
| 3. Jornada | 26.09.2021 | Progreso | - | Cerrito | 0:1 | |
|||
| 6. Jornada | 17.10.2021 | Cerro Largo | - | Progreso | 1:0 | ||||
| 10. Jornada | 04.11.2021 | Progreso | - | Fénix | 1:0 | ||||
| 11. Jornada | 08.11.2021 | Boston River | - | Progreso | 0:0 | |
|||
| 12. Jornada | 15.11.2021 | Progreso | - | Montevideo Wanderers | 3:1 |  |
|||
| 13. Jornada | 21.11.2021 | Rentistas | - | Progreso | 0:1 | ||||
| 14. Jornada | 25.11.2021 | Progreso | - | Peñarol | 0:0 | ||||
| 15. Jornada | 04.12.2021 | Montevideo City Torque | - | Progreso | 1:0 |
Uruguay