| 1. Jornada | 26.07.2015 | Santos Laguna | - | Club León | 1:3 | ||||
| 2. Jornada | 02.08.2015 | Chiapas FC | - | Santos Laguna | 2:1 | ||||
| 3. Jornada | 08.08.2015 | Santos Laguna | - | Club Tijuana | 0:1 | ||||
| 5. Jornada | 15.08.2015 | Santos Laguna | - | CF América | 0:2 | ||||
| 6. Jornada | 23.08.2015 | CF Monterrey | - | Santos Laguna | 1:1 | ||||
| 8. Jornada | 14.09.2015 | Puebla FC | - | Santos Laguna | 0:1 | ||||
| 9. Jornada | 19.09.2015 | Santos Laguna | - | Atlas Guadalajara | 0:2 | ||||
| 10. Jornada | 27.09.2015 | CF Pachuca | - | Santos Laguna | 0:0 | ||||
| 11. Jornada | 30.09.2015 | Santos Laguna | - | Dorados de Sinaloa | 1:1 | ||||
| 12. Jornada | 04.10.2015 | Santos Laguna | - | Deportivo Toluca | 0:0 |  |
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| 13. Jornada | 17.10.2015 | CD Veracruz | - | Santos Laguna | 0:3 | |
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| 14. Jornada | 24.10.2015 | Santos Laguna | - | Cruz Azul | 1:2 |  |
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| 15. Jornada | 01.11.2015 | UANL Tigres | - | Santos Laguna | 2:2 | ||||
| 16. Jornada | 07.11.2015 | Santos Laguna | - | Monarcas Morelia | 2:3 | ||||
| 17. Jornada | 23.11.2015 | Deportivo Guadalajara | - | Santos Laguna | 0:3 | |
Chile
España 