| 2. Jornada | 21.07.2022 | Club Nacional | - | Resistencia SC | 1:1 | ||||
| 4. Jornada | 30.07.2022 | Club Nacional | - | Sol de América | 3:0 | ||||
| 5. Jornada | 07.08.2022 | Cerro Porteño | - | Club Nacional | 0:0 | ||||
| 6. Jornada | 15.08.2022 | Guaraní | - | Club Nacional | 1:1 |  |
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| 7. Jornada | 21.08.2022 | Club Nacional | - | Libertad | 0:2 | ||||
| 8. Jornada | 26.08.2022 | Guaireña FC | - | Club Nacional | 1:3 | ||||
| 9. Jornada | 04.09.2022 | Club Nacional | - | Tacuary | 1:0 | ||||
| 10. Jornada | 11.09.2022 | Sportivo Ameliano | - | Club Nacional | 1:2 | ||||
| 11. Jornada | 16.09.2022 | Club Nacional | - | Club Olimpia | 1:1 | ||||
| 12. Jornada | 19.09.2022 | Club Nacional | - | General Caballero DJLM | 1:0 | ||||
| 14. Jornada | 03.10.2022 | Club Nacional | - | 12 de Octubre de Itauguá | 1:0 | ||||
| 15. Jornada | 06.10.2022 | Sol de América | - | Club Nacional | 2:3 | ||||
| 17. Jornada | 17.10.2022 | Club Nacional | - | Guaraní | 2:0 | ||||
| 19. Jornada | 27.10.2022 | Club Nacional | - | Guaireña FC | 3:0 | ||||
| 20. Jornada | 31.10.2022 | Tacuary | - | Club Nacional | 2:1 |  |
Paraguay