| 1. Jornada | 11.02.2001 | River Plate | - | Estudiantes | 6:2 |  |
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| 2. Jornada | 14.02.2001 | Vélez Sarsfield | - | River Plate | 0:2 |  |
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| 3. Jornada | 17.02.2001 | River Plate | - | Colón de Santa Fe | 3:0 | ||||
| 4. Jornada | 25.02.2001 | Rosario Central | - | River Plate | 1:1 | ||||
| 5. Jornada | 04.03.2001 | River Plate | - | Independiente | 3:1 | ||||
| 6. Jornada | 10.03.2001 | Talleres de Córdoba | - | River Plate | 3:1 | ||||
| 7. Jornada | 18.03.2001 | River Plate | - | CA Los Andes | 2:0 | ||||
| 8. Jornada | 25.03.2001 | San Lorenzo | - | River Plate | 1:3 | ||||
| 9. Jornada | 01.04.2001 | River Plate | - | Chacarita Juniors | 1:0 | |
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| 10. Jornada | 08.04.2001 | Boca Juniors | - | River Plate | 3:0 | ||||
| 11. Jornada | 11.04.2001 | River Plate | - | Argentinos Juniors | 3:2 | ||||
| 12. Jornada | 14.04.2001 | Unión de Santa Fe | - | River Plate | 2:3 | |
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| 14. Jornada | 29.04.2001 | Newell's Old Boys | - | River Plate | 2:3 | |
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| 15. Jornada | 13.05.2001 | River Plate | - | Racing Club | 3:0 | ||||
| 16. Jornada | 20.05.2001 | Belgrano | - | River Plate | 1:3 | ||||
| 17. Jornada | 27.05.2001 | River Plate | - | Almagro | 5:1 | |
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| 18. Jornada | 05.06.2001 | Huracán | - | River Plate | 3:2 |  |
Paraguay