| 1. Jornada | 15.05.2021 | Montevideo Wanderers | - | Boston River | 1:0 | ||||
| 2. Jornada | 23.05.2021 | Montevideo Wanderers | - | Deportivo Maldonado | 0:0 | ||||
| 3. Jornada | 31.05.2021 | Rentistas | - | Montevideo Wanderers | 0:1 |  |
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| 4. Jornada | 07.06.2021 | Montevideo Wanderers | - | Peñarol | 0:0 | ||||
| 5. Jornada | 11.06.2021 | Montevideo City Torque | - | Montevideo Wanderers | 2:1 | ||||
| 6. Jornada | 19.06.2021 | Montevideo Wanderers | - | Villa Española | 3:0 | ||||
| 7. Jornada | 24.06.2021 | Nacional | - | Montevideo Wanderers | 3:0 | ||||
| 8. Jornada | 29.06.2021 | Montevideo Wanderers | - | Cerrito | 1:0 | ||||
| 9. Jornada | 06.07.2021 | Liverpool | - | Montevideo Wanderers | 2:1 | |
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| 10. Jornada | 10.07.2021 | Montevideo Wanderers | - | River Plate | 1:2 | ||||
| 11. Jornada | 17.07.2021 | Cerro Largo | - | Montevideo Wanderers | 2:0 | |
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| 12. Jornada | 31.07.2021 | Montevideo Wanderers | - | Progreso | 2:0 | |
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| 13. Jornada | 09.08.2021 | Sud América | - | Montevideo Wanderers | 1:0 | ||||
| 14. Jornada | 16.08.2021 | Montevideo Wanderers | - | Plaza Colonia | 0:2 |  |
Uruguay