| 1. Jornada | 07.02.2022 | River Plate | - | Montevideo Wanderers | 1:1 |  |
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| 2. Jornada | 14.02.2022 | Montevideo Wanderers | - | Cerro Largo | 1:0 | |
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| 3. Jornada | 20.02.2022 | Fénix | - | Montevideo Wanderers | 0:3 | ||||
| 4. Jornada | 26.02.2022 | Montevideo Wanderers | - | Defensor Sporting | 1:0 | ||||
| 5. Jornada | 13.03.2022 | Albion | - | Montevideo Wanderers | 1:1 | |
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| 6. Jornada | 20.03.2022 | Montevideo Wanderers | - | Nacional | 2:2 | |
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| 7. Jornada | 02.04.2022 | Danubio | - | Montevideo Wanderers | 0:0 | ||||
| 8. Jornada | 12.04.2022 | Montevideo Wanderers | - | Deportivo Maldonado | 0:1 | ||||
| 11. Jornada | 09.05.2022 | Peñarol | - | Montevideo Wanderers | 1:0 | |
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| 14. Jornada | 29.05.2022 | Plaza Colonia | - | Montevideo Wanderers | 1:0 | ||||
| 15. Jornada | 06.06.2022 | Montevideo Wanderers | - | Boston River | 1:2 |
Chile