| 1. Jornada | 22.07.2018 | Cruz Azul | - | Puebla FC | 3:0 | ||||
| 2. Jornada | 28.07.2018 | Puebla FC | - | Deportivo Toluca | 2:1 | ||||
| 3. Jornada | 06.08.2018 | Santos Laguna | - | Puebla FC | 2:0 | ||||
| 4. Jornada | 11.08.2018 | Puebla FC | - | CD Veracruz | 1:2 |  |
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| 6. Jornada | 22.08.2018 | Puebla FC | - | Atlas Guadalajara | 2:0 | |
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| 7. Jornada | 26.08.2018 | CF Pachuca | - | Puebla FC | 2:0 | ||||
| 8. Jornada | 01.09.2018 | Puebla FC | - | CF Monterrey | 2:1 |  |
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| 9. Jornada | 16.09.2018 | Gallos Blancos | - | Puebla FC | 0:1 | ||||
| 10. Jornada | 22.09.2018 | Puebla FC | - | CF América | 2:3 | |
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| 11. Jornada | 30.09.2018 | Pumas UNAM | - | Puebla FC | 2:2 | |
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| 13. Jornada | 22.10.2018 | Monarcas Morelia | - | Puebla FC | 2:0 | ||||
| 14. Jornada | 29.10.2018 | Club León | - | Puebla FC | 0:4 | |
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| 15. Jornada | 03.11.2018 | Puebla FC | - | Deportivo Guadalajara | 2:2 | ||||
| 16. Jornada | 11.11.2018 | UANL Tigres | - | Puebla FC | 6:1 | ||||
| 17. Jornada | 24.11.2018 | Puebla FC | - | Club Tijuana | 0:0 |  |
Uruguay
España 