| 1. Jornada | 18.10.2020 | Guaireña FC | - | Libertad | 0:3 |  |
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| 4. Jornada | 07.11.2020 | Guaireña FC | - | Cerro Porteño | 1:1 | ||||
| 5. Jornada | 11.11.2020 | River Plate | - | Guaireña FC | 1:2 | ||||
| 6. Jornada | 14.11.2020 | Guaireña FC | - | General Díaz | 1:1 | ||||
| 7. Jornada | 22.11.2020 | Club Nacional | - | Guaireña FC | 0:0 | ||||
| 8. Jornada | 28.11.2020 | Guaireña FC | - | San Lorenzo | 2:2 | ||||
| 9. Jornada | 06.12.2020 | 12 de Octubre de Itauguá | - | Guaireña FC | 3:0 | ||||
| 10. Jornada | 11.12.2020 | Guaireña FC | - | Sportivo Luqueño | 1:0 | ||||
| 11. Jornada | 19.12.2020 | Guaraní | - | Guaireña FC | 1:0 |
Paraguay