| 3. Jornada | 26.09.2021 | Boston River | - | Peñarol | 2:5 | ||||
| 9. Jornada | 30.10.2021 | Boston River | - | River Plate | 1:2 | ||||
| 10. Jornada | 04.11.2021 | Cerro Largo | - | Boston River | 1:1 | ||||
| 11. Jornada | 08.11.2021 | Boston River | - | Progreso | 0:0 | ||||
| 12. Jornada | 14.11.2021 | Sud América | - | Boston River | 1:2 | ||||
| 13. Jornada | 22.11.2021 | Boston River | - | Plaza Colonia | 2:0 |  |
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| 14. Jornada | 30.11.2021 | Fénix | - | Boston River | 0:0 | |
Uruguay