| 1. Jornada | 07.08.2021 | FC Chiasso | - | FC Stade Nyonnais | 3:0 | ||||
| 2. Jornada | 18.08.2021 | FC Chiasso | - | AC Bellinzona | 2:1 | ||||
| 3. Jornada | 22.08.2021 | BSC Young Boys II | - | FC Chiasso | 0:1 |  |
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| 4. Jornada | 28.08.2021 | FC Rapperswil-Jona | - | FC Chiasso | 0:5 | ||||
| 6. Jornada | 11.09.2021 | FC Basel 1893 II | - | FC Chiasso | 3:3 | ||||
| 13. Jornada | 31.10.2021 | FC Chiasso | - | SC Cham | 3:0 |  |
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| 14. Jornada | 06.11.2021 | FC Black Stars Basel | - | FC Chiasso | 0:3 | ||||
| 15. Jornada | 14.11.2021 | FC Chiasso | - | FC Bavois | 1:1 | |
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| 16. Jornada | 20.11.2021 | FC Stade Nyonnais | - | FC Chiasso | 1:0 | ||||
| 19. Jornada | 20.02.2022 | FC Chiasso | - | FC Rapperswil-Jona | 2:2 | ||||
| 20. Jornada | 27.02.2022 | FC Biel/Bienne | - | FC Chiasso | 1:3 | |
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| 23. Jornada | 20.03.2022 | FC Chiasso | - | Etoile Carouge FC | 3:0 | |
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| 24. Jornada | 26.03.2022 | FC Zürich II | - | FC Chiasso | 1:1 | ||||
| 28. Jornada | 16.04.2022 | SC Cham | - | FC Chiasso | 2:4 | ||||
| 29. Jornada | 23.04.2022 | FC Chiasso | - | FC Black Stars Basel | 2:0 | ||||
| 30. Jornada | 30.04.2022 | FC Bavois | - | FC Chiasso | 0:1 |
Suiza