| 2. Jornada | 20.08.2021 | Sliema Wanderers | - | Floriana FC | 0:0 | ||||
| 3. Jornada | 11.09.2021 | Gżira United | - | Sliema Wanderers | 1:1 | ||||
| 4. Jornada | 19.09.2021 | Sliema Wanderers | - | Gudja United | 2:3 | ||||
| 5. Jornada | 26.09.2021 | Sirens FC | - | Sliema Wanderers | 2:2 | ||||
| 6. Jornada | 17.10.2021 | Sliema Wanderers | - | Hibernians FC | 0:3 | ||||
| 7. Jornada | 24.10.2021 | St. Luċija FC | - | Sliema Wanderers | 0:0 |  |
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| 9. Jornada | 20.11.2021 | Sliema Wanderers | - | Valletta FC | 0:3 |  |
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| 10. Jornada | 27.11.2021 | Birkirkara FC | - | Sliema Wanderers | 2:0 |  |
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| 13. Jornada | 19.12.2021 | Floriana FC | - | Sliema Wanderers | 2:0 | ||||
| 14. Jornada | 18.01.2022 | Sliema Wanderers | - | Gżira United | 1:3 | ||||
| 15. Jornada | 22.01.2022 | Gudja United | - | Sliema Wanderers | 1:0 | |
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| 12. Jornada | 26.01.2022 | Sliema Wanderers | - | Balzan FC | 1:0 | |
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| 16. Jornada | 29.01.2022 | Sliema Wanderers | - | Sirens FC | 1:0 | |
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| 18. Jornada | 13.02.2022 | Sliema Wanderers | - | St. Luċija FC | 1:1 | ||||
| 19. Jornada | 20.02.2022 | Mosta FC | - | Sliema Wanderers | 1:0 | |
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| 21. Jornada | 06.03.2022 | Sliema Wanderers | - | Birkirkara FC | 0:0 | ||||
| 22. Jornada | 11.03.2022 | Hamrun Spartans | - | Sliema Wanderers | 3:1 |
Países Bajos