| 2. Jornada | 12.02.2018 | Club Olimpia | - | General Díaz | 3:1 | ||||
| 5. Jornada | 03.03.2018 | Sportivo Luqueño | - | General Díaz | 2:0 |  |
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| 6. Jornada | 11.03.2018 | General Díaz | - | Guaraní | 0:3 | ||||
| 8. Jornada | 17.03.2018 | General Díaz | - | Cerro Porteño | 1:0 |  |
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| 9. Jornada | 24.03.2018 | 3 de Febrero | - | General Díaz | 2:2 | ||||
| 10. Jornada | 02.04.2018 | General Díaz | - | Sol de América | 1:1 | ||||
| 13. Jornada | 21.04.2018 | General Díaz | - | Club Olimpia | 1:2 | ||||
| 14. Jornada | 27.04.2018 | Independiente CG | - | General Díaz | 2:3 | |
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| 15. Jornada | 06.05.2018 | Club Nacional | - | General Díaz | 3:1 | ||||
| 16. Jornada | 09.05.2018 | General Díaz | - | Sportivo Luqueño | 2:1 | |
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| 17. Jornada | 14.05.2018 | Guaraní | - | General Díaz | 2:2 | |
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| 18. Jornada | 19.05.2018 | General Díaz | - | Deportivo Santaní | 1:0 | ||||
| 19. Jornada | 27.05.2018 | Cerro Porteño | - | General Díaz | 4:1 | ||||
| 20. Jornada | 31.05.2018 | General Díaz | - | 3 de Febrero | 3:2 | ||||
| 21. Jornada | 04.06.2018 | Sol de América | - | General Díaz | 4:3 | ||||
| 22. Jornada | 09.06.2018 | General Díaz | - | Libertad | 0:2 |
Argentina