| 5. Jornada | 26.09.2021 | Sirens FC | - | Sliema Wanderers | 2:2 | ||||
| 9. Jornada | 20.11.2021 | Sliema Wanderers | - | Valletta FC | 0:3 | ||||
| 10. Jornada | 27.11.2021 | Birkirkara FC | - | Sliema Wanderers | 2:0 |  |
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| 11. Jornada | 05.12.2021 | Sliema Wanderers | - | Hamrun Spartans | 0:2 | ||||
| 15. Jornada | 22.01.2022 | Gudja United | - | Sliema Wanderers | 1:0 | ||||
| 12. Jornada | 26.01.2022 | Sliema Wanderers | - | Balzan FC | 1:0 | ||||
| 16. Jornada | 29.01.2022 | Sliema Wanderers | - | Sirens FC | 1:0 | |
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| 17. Jornada | 05.02.2022 | Hibernians FC | - | Sliema Wanderers | 1:0 | ||||
| 18. Jornada | 13.02.2022 | Sliema Wanderers | - | St. Luċija FC | 1:1 | ||||
| 19. Jornada | 20.02.2022 | Mosta FC | - | Sliema Wanderers | 1:0 | ||||
| 20. Jornada | 26.02.2022 | Valletta FC | - | Sliema Wanderers | 1:0 | ||||
| 22. Jornada | 11.03.2022 | Hamrun Spartans | - | Sliema Wanderers | 3:1 | |
Malta