| 1. Jornada | 17.10.2020 | Club Olimpia | - | Club Nacional | 1:1 | ||||
| 2. Jornada | 25.10.2020 | San Lorenzo | - | Club Nacional | 1:1 | ||||
| 4. Jornada | 08.11.2020 | Sportivo Luqueño | - | Club Nacional | 1:3 |  |
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| 6. Jornada | 15.11.2020 | Libertad | - | Club Nacional | 0:2 | ||||
| 7. Jornada | 22.11.2020 | Club Nacional | - | Guaireña FC | 0:0 | ||||
| 8. Jornada | 30.11.2020 | Sol de América | - | Club Nacional | 2:3 | ||||
| 9. Jornada | 08.12.2020 | Club Nacional | - | Cerro Porteño | 4:3 | ||||
| 10. Jornada | 12.12.2020 | River Plate | - | Club Nacional | 1:1 | ||||
| 11. Jornada | 17.12.2020 | Club Nacional | - | General Díaz | 2:2 |
Paraguay