| 3. Jornada | 11.02.2023 | General Caballero DJLM | - | Club Nacional | 0:1 | ||||
| 5. Jornada | 24.02.2023 | Sportivo Ameliano | - | Club Nacional | 0:0 | ||||
| 6. Jornada | 04.03.2023 | Club Nacional | - | Guaraní | 0:2 | ||||
| 8. Jornada | 19.03.2023 | Club Nacional | - | Sportivo Luqueño | 0:1 | ||||
| 10. Jornada | 01.04.2023 | Tacuary | - | Club Nacional | 0:0 | ||||
| 12. Jornada | 12.04.2023 | Club Nacional | - | Guaireña FC | 2:2 | ||||
| 13. Jornada | 16.04.2023 | Club Olimpia | - | Club Nacional | 0:1 |  |
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| 14. Jornada | 24.04.2023 | Club Nacional | - | General Caballero DJLM | 2:0 | ||||
| 15. Jornada | 29.04.2023 | Libertad | - | Club Nacional | 2:1 | ||||
| 16. Jornada | 06.05.2023 | Club Nacional | - | Sportivo Ameliano | 1:0 |  |
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| 17. Jornada | 14.05.2023 | Guaraní | - | Club Nacional | 2:2 | ||||
| 18. Jornada | 19.05.2023 | Club Nacional | - | Resistencia SC | 0:0 | ||||
| 19. Jornada | 23.05.2023 | Sportivo Luqueño | - | Club Nacional | 0:1 | ||||
| 20. Jornada | 29.05.2023 | Club Nacional | - | Cerro Porteño | 2:1 | ||||
| 21. Jornada | 04.06.2023 | Club Nacional | - | Tacuary | 2:0 | ||||
| 22. Jornada | 11.06.2023 | Sportivo Trinidense | - | Club Nacional | 2:1 |
Paraguay