| 1. Jornada | 16.07.2022 | Tacuary | - | Guaireña FC | 0:0 | ||||
| 8. Jornada | 26.08.2022 | Guaireña FC | - | Club Nacional | 1:3 | ||||
| 9. Jornada | 02.09.2022 | Guaraní | - | Guaireña FC | 2:2 | ||||
| 10. Jornada | 10.09.2022 | Guaireña FC | - | Libertad | 4:0 | ||||
| 11. Jornada | 15.09.2022 | Cerro Porteño | - | Guaireña FC | 2:2 | ||||
| 12. Jornada | 19.09.2022 | Guaireña FC | - | Tacuary | 1:0 | ||||
| 13. Jornada | 23.09.2022 | Sportivo Ameliano | - | Guaireña FC | 2:0 | ||||
| 14. Jornada | 02.10.2022 | Guaireña FC | - | Club Olimpia | 0:1 | ||||
| 16. Jornada | 10.10.2022 | Guaireña FC | - | Resistencia SC | 3:2 | ||||
| 17. Jornada | 15.10.2022 | 12 de Octubre de Itauguá | - | Guaireña FC | 0:0 |  |
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| 19. Jornada | 27.10.2022 | Club Nacional | - | Guaireña FC | 3:0 | ||||
| 20. Jornada | 30.10.2022 | Guaireña FC | - | Guaraní | 1:0 | ||||
| 21. Jornada | 06.11.2022 | Libertad | - | Guaireña FC | 4:2 | ||||
| 22. Jornada | 12.11.2022 | Guaireña FC | - | Cerro Porteño | 1:3 |
Paraguay