| 4. Jornada | 05.02.2022 | CF América [Sub 20] | - | Atlético San Luis [Sub 20] | 0:1 | ||||
| 5. Jornada | 12.02.2022 | Atlético San Luis [Sub 20] | - | Deportivo Toluca [Sub 20] | 4:1 | ||||
| 6. Jornada | 19.02.2022 | UANL Tigres [Sub 20] | - | Atlético San Luis [Sub 20] | 1:1 | ||||
| 7. Jornada | 26.02.2022 | CF Monterrey [Sub 20] | - | Atlético San Luis [Sub 20] | 1:3 | ||||
| 8. Jornada | 02.03.2022 | Atlético San Luis [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 2:3 | ||||
| 9. Jornada | 06.04.2022 | Club Tijuana [Sub 20] | - | Atlético San Luis [Sub 20] | 2:1 |  |
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| 13. Jornada | 09.04.2022 | Atlético San Luis [Sub 20] | - | Club León [Sub 20] | 1:1 |  |
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| 14. Jornada | 15.04.2022 | Club Necaxa [Sub 20] | - | Atlético San Luis [Sub 20] | 3:0 | ||||
| 15. Jornada | 20.04.2022 | Atlético San Luis [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 | |
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| 16. Jornada | 24.04.2022 | Cruz Azul [Sub 20] | - | Atlético San Luis [Sub 20] | 2:2 | ||||
| 17. Jornada | 01.05.2022 | Atlético San Luis [Sub 20] | - | Santos Laguna [Sub 20] | 2:2 | |
México
Estados Unidos