| 4. Jornada | 30.07.2021 | Patronato de Paraná II | - | Newell's Old Boys II | 1:2 | ||||
| 6. Jornada | 16.08.2021 | Racing Club II | - | Newell's Old Boys II | 1:1 | ||||
| 7. Jornada | 20.08.2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 9. Jornada | 30.08.2021 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 | ||||
| 10. Jornada | 03.09.2021 | Colón de Santa Fe II | - | Newell's Old Boys II | 1:1 | ||||
| 11. Jornada | 10.09.2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Jornada | 17.09.2021 | Lanús II | - | Newell's Old Boys II | 0:2 | ||||
| 14. Jornada | 01.10.2021 | Godoy Cruz II | - | Newell's Old Boys II | 1:1 |  |
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| 18. Jornada | 22.10.2021 | Sarmiento de Junín II | - | Newell's Old Boys II | 1:2 | ||||
| 21. Jornada | 17.11.2021 | Arsenal de Sarandí II | - | Newell's Old Boys II | 0:3 |
Argentina