| 1. Jornada | 08.01.2022 | Deportivo Guadalajara [] | - | Atlético San Luis [] | 2:0 | ||||
| 2. Jornada | 15.01.2022 | CF Monterrey [] | - | Deportivo Guadalajara [] | 1:1 | ||||
| 7. Jornada | 19.02.2022 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 2:0 | ||||
| 9. Jornada | 05.03.2022 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 2:2 | ||||
| 10. Jornada | 12.03.2022 | Atlético San Luis [] | - | Deportivo Guadalajara [] | 0:2 | ||||
| 11. Jornada | 19.03.2022 | Deportivo Guadalajara [] | - | Club Tijuana [] | 3:0 |  |
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| 16. Jornada | 23.04.2022 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 2:1 | ||||
| 17. Jornada | 30.04.2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 4:0 | ||||
| 18. Jornada | 07.05.2022 | Deportivo Guadalajara [] | - | UANL Tigres [] | 2:1 |
México