| 1. Jornada | 19.01.2022 | Club León [Sub 20] | - | Atlas Guadalajara [Sub 20] | 1:1 | ||||
| 3. Jornada | 27.01.2022 | CF América [Sub 20] | - | Atlas Guadalajara [Sub 20] | 3:1 | ||||
| 6. Jornada | 20.02.2022 | Atlas Guadalajara [Sub 20] | - | Pumas UNAM [Sub 20] | 0:0 | ||||
| 7. Jornada | 26.02.2022 | Club Tijuana [Sub 20] | - | Atlas Guadalajara [Sub 20] | 2:1 | ||||
| 8. Jornada | 02.03.2022 | Atlas Guadalajara [Sub 20] | - | CF Pachuca [Sub 20] | 0:3 | ||||
| 9. Jornada | 05.03.2022 | Gallos Blancos [Sub 20] | - | Atlas Guadalajara [Sub 20] | 0:1 | ||||
| 10. Jornada | 11.03.2022 | FC Juárez [Sub 20] | - | Atlas Guadalajara [Sub 20] | 0:0 | ||||
| 14. Jornada | 14.04.2022 | Atlas Guadalajara [Sub 20] | - | Mazatlán FC [Sub 20] | 3:1 | ||||
| 15. Jornada | 20.04.2022 | CF Monterrey [Sub 20] | - | Atlas Guadalajara [Sub 20] | 0:0 |  |
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| 16. Jornada | 24.04.2022 | Deportivo Toluca [Sub 20] | - | Atlas Guadalajara [Sub 20] | 2:1 | ||||
| 17. Jornada | 30.04.2022 | Atlas Guadalajara [Sub 20] | - | UANL Tigres [Sub 20] | 0:0 |
México