| 3. Jornada | 08.08.2021 | Pumas UNAM [Sub 20] | - | Atlético San Luis [Sub 20] | 5:3 | ||||
| 6. Jornada | 21.08.2021 | Atlético San Luis [Sub 20] | - | Cruz Azul [Sub 20] | 0:0 | ||||
| 9. Jornada | 16.09.2021 | Atlético San Luis [Sub 20] | - | Club Tijuana [Sub 20] | 3:0 | ||||
| 10. Jornada | 26.09.2021 | Deportivo Toluca [Sub 20] | - | Atlético San Luis [Sub 20] | 2:0 |
México