| 2. Jornada | 15.01.2022 | Atlas Guadalajara [Sub 20] | - | Atlético San Luis [Sub 20] | 1:3 | ||||
| 4. Jornada | 05.02.2022 | CF América [Sub 20] | - | Atlético San Luis [Sub 20] | 0:1 |  |
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| 6. Jornada | 19.02.2022 | UANL Tigres [Sub 20] | - | Atlético San Luis [Sub 20] | 1:1 | ||||
| 11. Jornada | 17.03.2022 | Gallos Blancos [Sub 20] | - | Atlético San Luis [Sub 20] | 3:0 | ||||
| 9. Jornada | 06.04.2022 | Club Tijuana [Sub 20] | - | Atlético San Luis [Sub 20] | 2:1 |
México