| 5. Jornada | 04.07.2016 | Sporting Kansas City | - | Columbus Crew | 3:2 | ||||
| 5. Jornada | 10.07.2016 | New England Revolution | - | Columbus Crew | 3:1 | ||||
| 5. Jornada | 14.07.2016 | Columbus Crew | - | Toronto FC | 1:1 | ||||
| 5. Jornada | 24.07.2016 | Columbus Crew | - | Orlando City | 2:2 | ||||
| 5. Jornada | 01.08.2016 | Toronto FC | - | Columbus Crew | 3:0 | ||||
| 6. Jornada | 21.08.2016 | New England Revolution | - | Columbus Crew | 0:2 | ||||
| 6. Jornada | 25.08.2016 | Columbus Crew | - | Philadelphia Union | 1:2 | ||||
| 6. Jornada | 28.08.2016 | Columbus Crew | - | San Jose Earthquakes | 2:0 | ||||
| 7. Jornada | 04.09.2016 | Los Angeles Galaxy | - | Columbus Crew | 2:1 | ||||
| 7. Jornada | 18.09.2016 | Orlando City | - | Columbus Crew | 1:4 | ||||
| 7. Jornada | 26.09.2016 | Columbus Crew | - | New England Revolution | 2:0 | ||||
| 7. Jornada | 29.09.2016 | D.C. United | - | Columbus Crew | 3:0 | ||||
| 8. Jornada | 02.10.2016 | Columbus Crew | - | Chicago Fire | 3:0 |  |
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| 8. Jornada | 14.10.2016 | Chicago Fire | - | Columbus Crew | 2:2 | ||||
| 8. Jornada | 16.10.2016 | New York RB | - | Columbus Crew | 3:2 |
Estados Unidos