| 2. Jornada | 03.05.2021 | Vancouver Whitecaps | - | Colorado Rapids | 0:1 | ||||
| 2. Jornada | 09.05.2021 | Colorado Rapids | - | Minnesota United FC | 3:2 | ||||
| 2. Jornada | 30.05.2021 | Colorado Rapids | - | FC Dallas | 3:0 | ||||
| 3. Jornada | 20.06.2021 | FC Cincinnati | - | Colorado Rapids | 0:2 | ||||
| 4. Jornada | 08.07.2021 | Colorado Rapids | - | Minnesota United FC | 2:0 | ||||
| 4. Jornada | 22.07.2021 | Colorado Rapids | - | FC Dallas | 2:0 | ||||
| 5. Jornada | 01.08.2021 | Austin FC | - | Colorado Rapids | 0:1 | ||||
| 6. Jornada | 05.09.2021 | San Jose Earthquakes | - | Colorado Rapids | 0:1 | ||||
| 6. Jornada | 30.09.2021 | Colorado Rapids | - | Austin FC | 3:0 | ||||
| 7. Jornada | 10.10.2021 | Minnesota United FC | - | Colorado Rapids | 1:3 | ||||
| 7. Jornada | 28.10.2021 | New England Revolution | - | Colorado Rapids | 1:0 | ||||
| 7. Jornada | 31.10.2021 | Houston Dynamo | - | Colorado Rapids | 0:1 |
Estados Unidos