| 2. Jornada | 16.01.2022 | Club Tijuana | - | Club León | 1:1 | ||||
| 3. Jornada | 29.01.2022 | Puebla FC | - | Club Tijuana | 3:1 | ||||
| 5. Jornada | 12.02.2022 | Mazatlán FC | - | Club Tijuana | 2:0 | ||||
| 6. Jornada | 19.02.2022 | Club Tijuana | - | Club Necaxa | 1:1 | ||||
| 7. Jornada | 26.02.2022 | Club Tijuana | - | Atlas Guadalajara | 2:0 | ||||
| 8. Jornada | 02.03.2022 | Deportivo Toluca | - | Club Tijuana | 1:2 | ||||
| 10. Jornada | 14.03.2022 | Santos Laguna | - | Club Tijuana | 4:0 | ||||
| 12. Jornada | 04.04.2022 | UANL Tigres | - | Club Tijuana | 2:0 | ||||
| 17. Jornada | 01.05.2022 | CF Monterrey | - | Club Tijuana | 2:0 |  |
México