| 3. Jornada | 21.07.2016 | Club Nacional | - | Sol de América | 2:1 | ||||
| 4. Jornada | 26.07.2016 | Club Nacional | - | Sportivo Luqueño | 1:2 | ||||
| 6. Jornada | 07.08.2016 | Club Nacional | - | General Díaz | 1:2 |  |
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| 7. Jornada | 15.08.2016 | Guaraní | - | Club Nacional | 1:0 | |
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| 8. Jornada | 20.08.2016 | Club Nacional | - | Club Olimpia | 3:4 | |
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| 10. Jornada | 10.09.2016 | Club Nacional | - | General Caballero ZC | 4:1 | |
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| 11. Jornada | 18.09.2016 | River Plate | - | Club Nacional | 2:3 | ||||
| 12. Jornada | 25.09.2016 | Deportivo Capiatá | - | Club Nacional | 0:1 | ||||
| 13. Jornada | 03.10.2016 | Club Nacional | - | Cerro Porteño | 1:6 | ||||
| 14. Jornada | 15.10.2016 | Sol de América | - | Club Nacional | 0:1 |  |
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| 15. Jornada | 24.10.2016 | Sportivo Luqueño | - | Club Nacional | 2:1 | |
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| 17. Jornada | 07.11.2016 | General Díaz | - | Club Nacional | 0:2 | |
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| 18. Jornada | 21.11.2016 | Club Nacional | - | Guaraní | 1:1 | |
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| 19. Jornada | 27.11.2016 | Club Olimpia | - | Club Nacional | 2:1 | |
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| 20. Jornada | 04.12.2016 | Club Nacional | - | Club Rubio Ñu | 3:1 | ||||
| 21. Jornada | 11.12.2016 | General Caballero ZC | - | Club Nacional | 1:2 | |
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| 22. Jornada | 18.12.2016 | Club Nacional | - | River Plate | 2:0 |
Paraguay