| 2. Jornada | 20.03.2021 | FK Minsk | - | Rukh Brest | 2:2 | ||||
| 5. Jornada | 18.04.2021 | Rukh Brest | - | FK Smorgon | 5:0 | ||||
| 12. Jornada | 13.06.2021 | Rukh Brest | - | Torpedo-BelAZ Zhodino | 3:0 |  |
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| 13. Jornada | 19.06.2021 | FK Vitebsk | - | Rukh Brest | 0:0 | ||||
| 14. Jornada | 27.06.2021 | Rukh Brest | - | FK Slutsk | 1:0 | ||||
| 15. Jornada | 04.07.2021 | Dinamo Brest | - | Rukh Brest | 1:1 |  |
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| 16. Jornada | 17.07.2021 | FK Gomel | - | Rukh Brest | 0:0 | |
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| 18. Jornada | 30.07.2021 | Energetik-BGU Minsk | - | Rukh Brest | 0:2 | ||||
| 22. Jornada | 12.09.2021 | FK Slaviya Mozyr | - | Rukh Brest | 1:1 | |
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| 24. Jornada | 25.09.2021 | Rukh Brest | - | BATE Borisov | 2:2 | |
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| 25. Jornada | 01.10.2021 | Neman Grodno | - | Rukh Brest | 0:1 | ||||
| 26. Jornada | 17.10.2021 | Rukh Brest | - | Dinamo Minsk | 1:3 | ||||
| 27. Jornada | 24.10.2021 | Torpedo-BelAZ Zhodino | - | Rukh Brest | 3:3 | ||||
| 28. Jornada | 05.11.2021 | Rukh Brest | - | FK Vitebsk | 2:0 | ||||
| 29. Jornada | 20.11.2021 | FK Slutsk | - | Rukh Brest | 3:0 |  |
Albania