| 1. Jornada | 24.01.2019 | Guaraní | - | Cerro Porteño | 0:1 | ||||
| 2. Jornada | 26.01.2019 | Club Nacional | - | Guaraní | 0:2 | ||||
| 3. Jornada | 02.02.2019 | Guaraní | - | Libertad | 3:1 | ||||
| 8. Jornada | 28.02.2019 | Deportivo Santaní | - | Guaraní | 1:1 | ||||
| 9. Jornada | 04.03.2019 | Guaraní | - | River Plate | 2:1 |  |
|||
| 10. Jornada | 11.03.2019 | Sol de América | - | Guaraní | 1:4 | |
|||
| 15. Jornada | 09.04.2019 | Guaraní | - | San Lorenzo | 4:1 | |
|||
| 16. Jornada | 13.04.2019 | Deportivo Capiatá | - | Guaraní | 0:1 |  |
|||
| 14. Jornada | 18.04.2019 | Libertad | - | Guaraní | 1:1 | ||||
| 17. Jornada | 23.04.2019 | Guaraní | - | Sportivo Luqueño | 2:2 | ||||
| 22. Jornada | 18.05.2019 | Club Olimpia | - | Guaraní | 2:0 |
Paraguay