| 2. Jornada | 15.01.2022 | Deportivo Toluca [] | - | Club Necaxa [] | 2:1 | ||||
| 3. Jornada | 22.01.2022 | Club Necaxa [] | - | Cruz Azul [] | 4:1 | ||||
| 4. Jornada | 29.01.2022 | FC Juárez [] | - | Club Necaxa [] | 1:0 | ||||
| 5. Jornada | 05.02.2022 | Club Necaxa [] | - | Puebla FC [] | 4:0 | ||||
| 6. Jornada | 12.02.2022 | Club Necaxa [] | - | CF Pachuca [] | 2:1 | ||||
| 7. Jornada | 19.02.2022 | CF América [] | - | Club Necaxa [] | 3:3 | ||||
| 8. Jornada | 26.02.2022 | Club Necaxa [] | - | Gallos Blancos [] | 3:1 | ||||
| 13. Jornada | 03.04.2022 | Club Necaxa [] | - | CF América [] | 1:2 | ||||
| 16. Jornada | 23.04.2022 | Club Necaxa [] | - | FC Juárez [] | 1:0 | ||||
| 17. Jornada | 30.04.2022 | Club Necaxa [] | - | Pumas UNAM [] | 0:0 | ||||
| 18. Jornada | 07.05.2022 | Cruz Azul [] | - | Club Necaxa [] | 1:3 |  |
 |
México