| 1. Jornada | 07.01.2023 | Santos Laguna [] | - | Atlético San Luis [] | 5:0 | ||||
| 7. Jornada | 18.02.2023 | Club Tijuana [] | - | Santos Laguna [] | 2:0 | ||||
| 8. Jornada | 25.02.2023 | Santos Laguna [] | - | Mazatlán FC [] | 2:0 | ||||
| 9. Jornada | 04.03.2023 | UANL Tigres [] | - | Santos Laguna [] | 3:3 | ||||
| 10. Jornada | 11.03.2023 | Santos Laguna [] | - | Atlas Guadalajara [] | 3:0 | ||||
| 12. Jornada | 25.03.2023 | CF Monterrey [] | - | Santos Laguna [] | 2:1 | ||||
| 14. Jornada | 08.04.2023 | Mazatlán FC [] | - | Santos Laguna [] | 0:1 | ||||
| 15. Jornada | 15.04.2023 | Santos Laguna [] | - | Deportivo Guadalajara [] | 5:3 | ||||
| 16. Jornada | 22.04.2023 | Atlético San Luis [] | - | Santos Laguna [] | 0:1 | ||||
| 17. Jornada | 29.04.2023 | Club León [] | - | Santos Laguna [] | 3:0 |
México