| 9. Jornada | 10.04.2022 | General Caballero DJLM | - | Cerro Porteño | 0:0 | ||||
| 12. Jornada | 24.04.2022 | Sportivo Ameliano | - | Cerro Porteño | 0:1 |  |
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| 13. Jornada | 01.05.2022 | Cerro Porteño | - | Club Nacional | 1:0 | ||||
| 14. Jornada | 09.05.2022 | Guaraní | - | Cerro Porteño | 1:2 | ||||
| 20. Jornada | 22.06.2022 | Cerro Porteño | - | General Caballero DJLM | 3:1 | ||||
| 21. Jornada | 26.06.2022 | Libertad | - | Cerro Porteño | 1:0 |
Paraguay