| 1. Jornada | 25.07.2021 | FC Lugano | - | FC Zürich | 0:2 | ||||
| 2. Jornada | 31.07.2021 | FC Zürich | - | FC Lausanne-Sport | 3:1 | ||||
| 3. Jornada | 08.08.2021 | FC Luzern | - | FC Zürich | 1:3 | ||||
| 4. Jornada | 21.08.2021 | FC Zürich | - | Grasshopper Club Zürich | 2:1 | ||||
| 5. Jornada | 28.08.2021 | FC St. Gallen | - | FC Zürich | 3:3 | ||||
| 6. Jornada | 11.09.2021 | BSC Young Boys | - | FC Zürich | 4:0 | ||||
| 9. Jornada | 03.10.2021 | FC Zürich | - | FC Sion | 6:2 |  |
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| 16. Jornada | 04.12.2021 | FC Zürich | - | FC Luzern | 4:0 | ||||
| 17. Jornada | 11.12.2021 | FC Lausanne-Sport | - | FC Zürich | 1:3 | ||||
| 20. Jornada | 05.02.2022 | Grasshopper Club Zürich | - | FC Zürich | 1:3 | ||||
| 22. Jornada | 20.02.2022 | FC Sion | - | FC Zürich | 1:1 | ||||
| 26. Jornada | 12.03.2022 | FC Zürich | - | FC St. Gallen | 0:3 | ||||
| 28. Jornada | 02.04.2022 | FC Zürich | - | Grasshopper Club Zürich | 1:1 | ||||
| 29. Jornada | 10.04.2022 | Servette FC | - | FC Zürich | 1:0 | ||||
| 31. Jornada | 23.04.2022 | FC Zürich | - | FC Sion | 5:1 |  |
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| 32. Jornada | 01.05.2022 | Basilea | - | FC Zürich | 0:2 | ||||
| 34. Jornada | 12.05.2022 | FC Zürich | - | FC Lausanne-Sport | 2:2 | ||||
| 35. Jornada | 19.05.2022 | FC Lugano | - | FC Zürich | 2:1 | ||||
| 36. Jornada | 22.05.2022 | FC Zürich | - | FC Luzern | 2:3 |
Suiza