| 4. Jornada | 03.10.2021 | Montevideo City Torque | - | Boston River | 4:3 |  |
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| 5. Jornada | 10.10.2021 | Boston River | - | Villa Española | 1:0 | |
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| 6. Jornada | 16.10.2021 | Nacional | - | Boston River | 3:2 | |
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| 7. Jornada | 21.10.2021 | Boston River | - | Cerrito | 3:2 | ||||
| 8. Jornada | 24.10.2021 | Liverpool | - | Boston River | 2:2 | |
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| 9. Jornada | 30.10.2021 | Boston River | - | River Plate | 1:2 | |
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| 10. Jornada | 04.11.2021 | Cerro Largo | - | Boston River | 1:1 | ||||
| 11. Jornada | 08.11.2021 | Boston River | - | Progreso | 0:0 | ||||
| 12. Jornada | 14.11.2021 | Sud América | - | Boston River | 1:2 | ||||
| 13. Jornada | 22.11.2021 | Boston River | - | Plaza Colonia | 2:0 | ||||
| 14. Jornada | 30.11.2021 | Fénix | - | Boston River | 0:0 |  |
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| 15. Jornada | 04.12.2021 | Boston River | - | Deportivo Maldonado | 2:1 | |
Uruguay