| 1. Jornada | 03.04.2022 | Unión Comercio | - | Cusco FC | 1:0 | ||||
| 3. Jornada | 16.04.2022 | Cusco FC | - | Alfonso Ugarte | 2:2 |  |
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| 4. Jornada | 24.04.2022 | Chavelines Juniors | - | Cusco FC | 0:1 | |
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| 5. Jornada | 30.04.2022 | Cusco FC | - | Pirata | 2:0 | ||||
| 6. Jornada | 07.05.2022 | Llacuabamba | - | Cusco FC | 0:0 |  |
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| 7. Jornada | 15.05.2022 | Cusco FC | - | Los Chankas | 2:1 | |
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| 8. Jornada | 22.05.2022 | Santos FC | - | Cusco FC | 1:2 | ||||
| 9. Jornada | 28.05.2022 | Cusco FC | - | Deportivo Coopsol | 3:0 | ||||
| 10. Jornada | 05.06.2022 | Unión Huaral | - | Cusco FC | 0:1 | ||||
| 11. Jornada | 11.06.2022 | Cusco FC | - | Juan Aurich | 2:0 | |
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| 12. Jornada | 19.06.2022 | Alianza Universidad | - | Cusco FC | 0:2 | ||||
| 13. Jornada | 26.06.2022 | Cusco FC | - | Comerciantes Unidos | 3:2 | |
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